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Sudha Agarwal, Ph.D.
Professor
The Ohio State University College of Dentistry
4010 Postle Hall
305 West 12th Ave.
Columbus, OH 43210
Phone: (614) 688-5935
Fax: (614) 247-7475
Email:
agarwal.61@osu.edu
Education & Training:
Northeastern University, Boston, 1973, Ph. D. in Cell Physiology
Massachusetts
General Hospital, Boston, 1972-73 Post-doc, Immunology
Johns Hopkins University
School of Medicine, Baltimore, 1983-87 Post-doc, Immunology
Research Interests:
(1) Mechanotransduction: Intracellular mechanisms of Stress-induced
signal transduction in musculoskeletal cells and tissues. This project
involves examination of the intracellular mechanisms of cartilage/muscle
repair by mechanical signals in vitro and in vivo. Mechanical signals play
major role in augmenting host’s ability to regenerate and /or repair
musculoskeletal tissues. For example, continuous passive motion/exercise
is known to induce faster repair and regeneration of post-surgical joints,
exercise is beneficial for arthritic joints, muscle regeneration etc. However,
the mechanisms by which mechanical signals act on the cells of cartilage/muscle
during inflammation are as yet unknown. We observed that mechanical forces
of physiological magnitudes are potent anti-inflammatory and reparative
signals in chondrocytes. We are now extending these studies to examine
the signal transduction pathways that are important in tissue regeneration
as well as curbing the inflammation, i.e., NF-kB, SMAD, and AkT signaling
pathways. With the advancements in tissue engineering, understanding the
pathways that enhance tissue’s ability to self-regenerate are quite
important. These pathways once delineated can then be applied in an effective
manner to augment regenerative capacity of diseased and aging cartilage/muscle
as well as allow better integration of tissue engineered transplants, to
repair joints inflicted with arthritic diseases.
Selected Publications:
- Deschner J, Rath-Deschner B, Agarwal S. (2006) Regulation
of matrix metalloproteinase expression by dynamic tensile strain in
rat fibrochondrocytes. Osteoarthritis Cartilage. 14(3):264-72.
PMID: 16290189
- Ferretti M, Madhavan S, Deschner J, Rath-Deschner B, Wypasek E, Agarwal
S. (2006) Dynamic biophysical strain modulates proinflammatory gene
induction in meniscal fibrochondrocytes. Am J Physiol (Cell Physiol) 290(6):C1610-5.
PMID: 16452158
- Madhavan S, Anghelina M, Rath-Deschner B, Wypasek E, John A, Deschner
J, Piesco N, Agarwal S. (2006) Biomechanical signals exert sustained
attenuation of proinflammatory gene induction in articular chondrocytes. Osteoarthritis
Cartilage. 10:1023-32.
- Ferretti M, Gassner R, Wang Z, Perera P, Deschner J, Sowa G, Salter
RB, Agarwal S. (2006) Biomechanical signals suppress proinflammatory
responses in cartilage: early events in experimental antigen-induced
arthritis. J Immunol. 177(12):8757-66. PMID:
17142778
- Chandran R, Knobloch TJ, Agarwal S. (2007) Biomechanical signals
upregulate myogenic gene induction in the presence or absence of inflammation. Am
J Physiol Cell Physiol, Jul 2007; 293: C267 - C276. PMID: 17392379
- Dossumbekova A, Anghelina M, Madhavan S, He L, Knobloch
TJ, Agarwal S. (2007) Biomechanical signals Inhibit IKK activity to
attenuate NF-kB transcriptional activity in inflamed chondrocytes. Arth & Rheumat.
56(10):3284-3296 PMID: 17907174
- Madhavan S, Anghelina M, Sjostrom D, Dossumbekova A, Guttridge D,
Agarwal S. (2007) Biomechanical Signals use TAK1 as a Molecular Switch
to Inhibit Inflammation in Chondrocytes. J Immunol. 2007 179(9):6246-54.
PMID: 17947700
- Butterfield TA, Zhao Y, Agarwal S, Haq F, Best TM. (2008) Cyclic
compressive loading facilitates recovery following eccentric exercise. Medicine
and Science in Sports & Exercise. 40(7):1289-1296.
- Anghelina M, Sjostrom D, Priyangi P, Nam J, Knobloch TJ, Agarwal
S. (2008) The NF-kB Transcription Factors and Biomechanical Signals
in Chondrocytes. Biorheology, 5th International Symposium in Mechanobiology
of Cartilage and Chondrocyte, Invited review, Bioreology,
45(2-3):245-256. PMID: 18836228.
- Chen Q, Zhang H, Li Q, An Y, Herkenham M, Lai W, Popovich P, Agarwal
S, and Quan N. (2009) Three promotors regulate tissue and cell specific
expression of murine IL-1R1. J. Biol Chem, e-pub Feb 5 2009.
PMID: 19196714
- Nam J, Aguda B, Rath B. Agarwal S. (2009) Biomechanical Thresholds
Regulating Inflammation through the NF-kB Pathway: Experiments and
Modeling. PLoS One, 4:e5262.
- Agarwal S, Nam J, Liu J, Perera P, and Agarwal S. (2009) NF-kB signaling
cascade in mechano-transduction. Invited review. Innate Immunity.
In press.
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