| |
|
Peter J. Houghton, Ph.D.
Director of Center for Childhood Cancer
Nationwide Children’s Research Institute
Center for Childhood Cancer
700 Children’s Drive
Columbus, OH 43205
Phone: (614) 355-2670
Email:
Peter.Houghton@nationwidechildrens.org
Education & Training:
University of Bradford, Yorkshire, England, 1972 B.Ph.
University
of London, Institute of Cancer Research, Sutton, Surrey, England, 1976
Ph.D.
Research Interests:
Biology and therapy of Rhabdomyosarcoma, and other childhood
tumors
IGF-I signaling as a therapeutic target
IGF-I mediated survival pathways
in malignant cells derived from childhood tumors
Chemotherapy of childhood
solid tumors
Selected Publications:
- Huang, S., Shu, L., Dilling, M.B., Easton J., Harwood, F.C., Ichijo,
H., Houghton, P.J. (2003) Sustained activation of the JNK cascade and
rapamycin-induced apoptosis are suppressed by p53/p21 cip1. Molecular
Cel, 11:1-20.
- Houghton, P.J., Germain, G.S., Harwood, F.C., Schuetz, J.D., Stewart,
C.F., Buchdunger, E., Traxler, P (2004) Imatinib mesylate is a potent
inhibitor of the ABCG2 (BCRP) transporter and reverses resistance to
topotecan and SN-38 in vitro. Cancer Res, 64:2333-2337.
- Huang, S., Shu, L., Easton, J., Harwood, F.C., Germain, G.S., Ichijo,
H., Houghton, P.J. (2004) Inhibition of mammalian target of rapamycin
activates apoptosis signal-regulating kinase 1 signaling by suppressing
protein phosphatase 5 activity. J Biol Chem, 279:36490-36496.
- Peterson, J.K., Tucker, C., Favours, E., Cheshire, P.J., Creech,
J., Billups, C.A., Smykla, R., Lee, F.Y., Houghton, P.J. (2005) In
vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative,
against pediatric cancer models. Clin Cancer Res,11:6950-8.
- Graham C, Tucker C, Creech J, Favours E, Billups CA, Liu T, Fouladi
M, Freeman BB 3rd, Stewart CF, Houghton P.J. (2003) Evaluation
of the antitumor efficacy, pharmacokinetics, and pharmacodynamics of
the histone deacetylase inhibitor depsipeptide in childhood cancer
models in vivo. Clin Cancer Res.12:223-34.
- Furman, W.L., Crews, K.R., Billups, C., Wu, J., Gajjar, A.J., Daw,
N.C., Patrick, C.C., Rodriguez-Galindo, C., Stewart, C.F., Dome, J.S.,
Panetta, J.C., Houghton, P.J., Santana, V.M. (2006) Cefixime
allows greater dose escalation of oral irinotecan: a phase I study
in pediatric patients with refractory solid tumors. J Clin Oncol.
24:563-70.
- Stupack, D.G., Teitz, T., Potter, M.D., Mikolon, D., Houghton, P.J.,
Kidd, V.J., Lahti, J.M., Cheresh, D.A. (2006) Potentiation of neuroblastoma
metastasis by loss of caspase-8. Nature, 439:95-9.
- Zhan, J., Easton, J.B., Huang, S., Mishrar, A., Xiao, L., Lacy, E.R.,
Kriwacki, R.W., Houghton, P.J. (2007) Negative regulation of
ASK1 by p21CIP1 involves a small domain that includes serine 98 that
is phosphorylated by Ask1 in vivo. Mol Cell Biol, 27:3530-3541.
- Kurmasheva, R.T., Harwood, F.C., Houghton, P.J. (2007) Differential
regulation of vascular endothelial growth factor by Akt and mTOR in
cell lines derived from childhood solid tumors. Mol Cancer Ther,
6:1620-8.
- Houghton, P.J., Morton, C.L., Kolb, E.A., Lock, R., Carol, H., Reynolds,
C.P., Keshelava, N., Maris, J.M., Keir, S.T., Wu, J., Smith, M.A. (2007)
Initial testing (stage 1) of the proteasome inhibitor bortezomib by
the pediatric preclinical testing program. Pediatr Blood
Cancer, Apr 9: PMID: 17420992.
- Harwood, F.C., Shu, L., Houghton, P.J. (2008) mTORC1 signaling can
regulate growth factor activation of p44/42 mitogen-activated protein
kinases through protein phosphatase 2A. J Biol Chem, 283(5):2575-2585.
- Neale, G., Su, X., Morton, C.L., et al. (2008) Molecular characterization
of the pediatric preclinical testing panel. Clin Cancer Res,
14(14):4572-4583.
- Kurmasheva, R.T., Dudkin, L., Billups, C., Debelenko, L.V., Morton,
C.L., Houghton, P.J. (2009) The insulin-like growth factor-1 receptor-targeting
antibody, CP-751,871, suppresses tumor-derived VEGF and synergizes
with rapamycin in models of childhood sarcoma. Cancer Res,
69:7662-71.
-
Shu L, Houghton PJ. (2009) The mTORC2 complex regulates terminal differentiation
of C2C12 myoblasts. Mol Cell Biol. 29:4691-700.
|
|
