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Donna McCarthy Beckett, Ph.D. ,
RN, FAAN
Professor and Assoc. Dean for Research
The Ohio State University College of Nursing
350 Newton Hall
1585 Neil
Avenue
Columbus, OH 43210
Phone: (614) 292-2356
Email:
mccarthy.225@osu.edu
Education & Training:
University of Wisconsin, Milwaukee, 1971 B.S. in Nursing
Marquette
University, Milwaukee, Wisconsin, 1973 M.S. in Nursing
University of Michigan,
Ann Arbor, Michigan, 1985 Ph.D.
University of Rochester, New York, 1987
Postdoctoral Fellow
Research Interest:
Cachexia is a poorly understood syndrome of anorexia, unintended
weight loss, and wasting of skeletal muscle mass. It is a major cause
of morbidity and mortality in cancer patients. Work in my laboratory
focuses on translating basic research on the patho-biology of tumor-induced
muscle wasting into clinically-relevant interventions to preserve muscle
mass in cancer patients. We use mouse models of cancer cachexia,
including the Colon-26 adenocarcinoma, the B16 melanoma, and the Lewis
lung carcinoma. We have examined the effects of nonsteroidal anti-inflammatory
drugs, physical exercise, and neutraceuticals on muscle mass and tumor
growth using these models.
Selected Publications:
- McCarthy DO. Cytokines and the anorexia of infection: Potential
mechanisms and treatments. [Invited review] Bio Res Nurs 2000; 1: 287-298.
- McCarthy DO. Tumor necrosis factor and interleukin-6 have differential
effects on food intake and gastric emptying of rats. Res Nurs & Health 2000; 23: 222-228.
- Al-Majid S, McCarthy DO. Resistance exercise training attenuates
wasting of the EKL muscle in mice bearing the Colon-26 adenocarcinoma.
Bio Res Nurs 2001; 2: 155-166.
- Al-Majid S, McCarthy DO. Cancer-induced fatigue and skeletal muscle
wasting: The role of exercise. Bio Res Nurs 2001; 2: 186-197.
- Diffee GM, Kalfas K, Al-Majid S, McCarthy DO. Altered expression
of skeletal muscle myosin isoforms in cancer cachexia. Am J Phys 2002;
283: C1376-1382.
- McCarthy DO, Whitney P, Hitt A, Al-Majid S. Indomethacin and ibuprofen
preserve gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma.
Res Nurs & Health 2004; 27: 174-184.
- Hitt A, Graves E, McCarthy DO. Indomethacin preserves muscle mass
and reduces levels of E3 ligases and TNF receptor type 1 in the gastrocnemius
muscle of tumor-bearing mice. Res Nurs Health 2005; 28: 56-66.
- Graves E, Hitt A, Pariza M, Cook M, McCarthy DO. Conjugated linoleic
acid preserves muscle mass in mice bearing the conon-26 adenocarcinoma.
Res Nurs & Health 2005; 28: 48-55.
- Graves E, Ramsay N, McCarthy DO. Inhibitors of COX activity preserve
muscle mass in mice bearing the Lewis lung carcinoma, but not the B16
melanoma. Res Nurs Health 2006; 29: 87-97.
- McCarthy DO, Graves E. Conjugated linoleic acid preserves muscle
mass in mice bearing the Lewis lung carcinoma, but not the B16 melanoma.
Res Nurs Health 2006; 29:98-104.
- McCarthy DO, Pycha K, Berg TC. Curcumin
reduces tumor growth but does not preserve muscle mass in a mouse
model of cancer cachexia. Oncology Nursing Forum 2008; 35: 455-459.
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