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2014 MVIMG 7470
Neuromuscular Biology and Disease – Duchenne Muscular Dystrophy
Thursdays 2:30-3:30pm, Parks Hall 103
Instructors: Jill Rafael-Fortney, PhD and Denis Guttridge, PhD
Course schedule:
MVIMG 7470 Spring 2014 DMD Course Syllabus (download PDF)
WEEK 1 – Jan 9
Clinical / genetics / diagnosis overview - Kevin Flanigan, M.D.
History of dystrophin gene cloning - Arthur Burghes, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 2 – Jan 16
Overview of skeletal and cardiac muscle physiology and measurements - Paul Janssen, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 3 – Jan 23
Histopathology / pathophysiology overview - Zarife Sahenk, M.D., Ph.D. / Jill Rafael-Fortney, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 4 – Jan 30
Dystrophin glycoprotein complex discovery and associations - Rachelle Crosbie, Ph.D. (UCLA)
Click here to download a PDF of the slides used in this lecture.
WEEK 5 – Feb 6
Cardiomyopathy - Subha Raman, M.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 6 – Feb 13
Discussion of Darius Goes West - Denis Guttridge, Ph.D. and Jill Rafael-Fortney, Ph.D.
To watch the film Darius Goes West on-line, go to:
http://www.dariusgoeswest.org/playitforward/
WEEK 7 – Feb 20
Summary of preclinical and transgenic models - Jill Rafael-Fortney, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 8 – Feb 27
Membrane damage and repair - Noah Weisleder, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 9 – March 6
Glycosylation and membrane stabilization - Paul Martin, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 10 – March 20
Inflammation - Jim Tidball, Ph.D. (UCLA)
Click here to download a PDF of the slides used in this lecture.
WEEK 11 – March 27
Signaling pathways - Denis Guttridge, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 12 –April 3
Fibrosis - Federica Montanaro, Ph.D.
Click here to download a PDF of the slides used in this lecture.
WEEK 13 – April 10
Gene therapy / exon skipping / pre/neonatal-testing - Jerry Mendell, M.D.
WEEK 14 – April 17
Perspective from a parent and advocate - Pat Furlong, Parent Project Muscular Dystrophy
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