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Jonathan P. Davis , Ph.D.
Assistant Professor
The Ohio State University Medical Center
Department
of Physiology & Cell
Biology
1645 Neil Ave.
Columbus, OH 43210
Phone: (614) 247-2559
Email: davis.812@osu.edu
Education & Training:
Greenville College, Greenville, Illinois, B.A. in Mathematics
and Physics, 1993
The Ohio State University, Columbus, Ph.D. Biophysics, 1998
Emory University, Atlanta Go, Department of Cell Biology, Postdoc Fellow, 1999
The
Ohio State University, Department of Physiology and Cell Biology, Postdoc Fellow,
2003
Research Interest:
In our group, we are interested in elucidating the biochemical
and physiological mechanisms that determine the kinetics of cardiac and
skeletal muscle contraction and relaxation in health and disease through
the engineering of proteins. Specific interests include:
1) Determine the cellular and molecular basis of muscle contraction and relaxation.
2) Understand how calcium binding proteins/enzymes are appropriately “tuned” kinetically
to respond to calcium transients in vitro and in vivo.
3) Modulate cellular function through the design and engineering of calcium binding
proteins and/or their binding partners.
Selected Publications:
- Gomes, A.V., G. Venkatraman, J.P. Davis, S.B. Tikunova, P. Engel,
R.J. Solaro and J.D.
Potter, (2004) Cardiac troponin T isoforms affect the Ca2+ sensitivity of force
development in the presence of slow skeletal troponin I: insights into the
role of troponin T isoforms
in the fetal heart. J. Biol. Chem. 279: 49579-49587.
- Swartz, D.R., Z. Yang, A. Sen, S.B. Tikunova and Davis, J.P., (2006)
Myofibrillar troponin
exists in three states and there is signal transduction along skeletal myofibrillar
thin
filaments. J. Mol. Biol. 361: 420-435.
- Engel, P.L., T. Kobayashi, B. Biesiadecki, J.P. Davis, S.B. Tikunova,
S. Wu and R.J. Solaro, (2007) Identification of a region of troponin
I important in signaling cross-bridge-dependent
activation of cardiac myofilaments. J. Biol. Chem. 282:
183-193.
- Davis, J.P., Alionte, C., Kobayashi, T., Solaro, R.J., Swartz, D.R.,
and Tikunova, S.B., (2007) Effects of thin and thick filament proteins
on calcium binding and exchange with cardiac troponin C. Biophys.
J. 92: 3195-3206.
- Kreutziger, K.L., Gillis, T.E., Davis, J.P., Tikunova, S.B., and
Regnier, M., (2007) Influence of enhanced troponin C Ca2+ binding affinity
on cooperative thin filament activation in
rabbit skeletal muscle. J. Physiol. 583: 337-350.
- Norman, C., Rall, J.A., Tikunova, S.B., and Davis, J.P., (2007) Modulation
of the rate of cardiac muscle contraction by troponin C constructs
with various calcium binding affinities. Am. J. Physiol.
Heart Circ. Physiol. 293: H2580-2587.
- Davis, J.P. and Tikunova, S.B., (2008) Ca2+ exchange with troponin
C
and cardiac muscle dynamics. Cardiovasc. Res. 77: 619-626.
- Monasky, M.M., Varian, K.D., Davis, J.P., and Janssen, P.M., (2008)
Dissociation of force decline from calcium decline by preload in isolated
rabbit myocardium. Pflugers Arch. 456: 267-276.
- Liang, B., Chung, F., Yang, Q., Pavlov, D., Gillis, T.E., Tikunova,
B.S., Davis, J.P., and Tibbits, G.F., (2008) The familial hypertrophic
cardiomyopathy related cardiac troponin C mutation L29Q affects calcium
binding and myofilament contractility. Physiol. Genomics. 33:
257-266.
- Kohr, M.J., Davis, J.P., and Ziolo, M.T., (2009) Peroxynitrite
increases protein phosphatase activity and promotes the interaction
of phospholamban with protein phosphatase 2a in the myocardium. Nitric
Oxide. 20(3):217-221.
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