Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease

Jonathan P. Davis , Ph.D. Jonathan P. Davis , Ph.D.
Associate Professor

The Ohio State University Medical Center
Department of Physiology & Cell Biology
1645 Neil Ave.
Columbus, OH 43210

Phone: (614) 247-2559
Email: davis.812@osu.edu

Education & Training:
Greenville College, Greenville, Illinois, B.A. in Mathematics and Physics, 1993
The Ohio State University, Columbus, Ph.D. Biophysics, 1998
Emory University, Atlanta Go, Department of Cell Biology, Postdoc Fellow, 1999
The Ohio State University, Department of Physiology and Cell Biology, Postdoc Fellow, 2003

Research Interest:
In our group, we are interested in elucidating the biochemical and physiological mechanisms that determine the kinetics of cardiac and skeletal muscle contraction and relaxation in health and disease through the engineering of proteins.  Specific interests include:
1) Determine the cellular and molecular basis of muscle contraction and relaxation.
2) Understand how calcium binding proteins/enzymes are appropriately “tuned” kinetically to respond to calcium transients in vitro and in vivo.
3) Modulate cellular function through the design and engineering of calcium binding proteins and/or their binding partners.

Selected Publications:

  • Gomes, A.V., G. Venkatraman, J.P. Davis, S.B. Tikunova, P. Engel, R.J. Solaro and J.D.
    Potter, (2004) Cardiac troponin T isoforms affect the Ca2+ sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms
    in the fetal heart.  J. Biol. Chem. 279: 49579-49587.
  • Swartz, D.R., Z. Yang, A. Sen, S.B. Tikunova and Davis, J.P., (2006) Myofibrillar troponin
    exists in three states and there is signal transduction along skeletal myofibrillar thin
    filaments. J. Mol. Biol. 361: 420-435.
  • Engel, P.L., T. Kobayashi, B. Biesiadecki, J.P. Davis, S.B. Tikunova, S. Wu and R.J. Solaro, (2007) Identification of a region of troponin I important in signaling cross-bridge-dependent
    activation of cardiac myofilaments.   J. Biol. Chem. 282: 183-193.
  • Davis, J.P., Alionte, C., Kobayashi, T., Solaro, R.J., Swartz, D.R., and Tikunova, S.B., (2007) Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C.  Biophys. J. 92: 3195-3206.
  • Kreutziger, K.L., Gillis, T.E., Davis, J.P., Tikunova, S.B., and Regnier, M., (2007) Influence of enhanced troponin C Ca2+ binding affinity on cooperative thin filament activation in
    rabbit skeletal muscle.  J. Physiol. 583: 337-350.
  • Norman, C., Rall, J.A., Tikunova, S.B., and Davis, J.P., (2007) Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities.  Am. J. Physiol. Heart Circ. Physiol. 293: H2580-2587.
  • Davis, J.P. and Tikunova, S.B., (2008) Ca2+ exchange with troponin C
    and cardiac muscle dynamics.  Cardiovasc. Res. 77: 619-626.
  • Monasky, M.M., Varian, K.D., Davis, J.P., and Janssen, P.M., (2008) Dissociation of force decline from calcium decline by preload in isolated rabbit myocardium.  Pflugers Arch. 456: 267-276.
  • Liang, B., Chung, F., Yang, Q., Pavlov, D., Gillis, T.E., Tikunova, B.S., Davis, J.P., and Tibbits, G.F., (2008) The familial hypertrophic cardiomyopathy related cardiac troponin C mutation L29Q affects calcium binding and myofilament contractility.  Physiol. Genomics.  33: 257-266.
  • Kohr, M.J., Davis, J.P., and Ziolo, M.T., (2009) Peroxynitrite increases protein phosphatase activity and promotes the interaction of phospholamban with protein phosphatase 2a in the myocardium.  Nitric Oxide. 20(3):217-221.