Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease

Paul T. Martin, Ph.D. Paul T. Martin, Ph.D.

Center for Gene Therapy,
The Research Institute at Nationwide Children’s Hospital,
700 Children’s Drive,
Columbus, OH 43205

Phone: (614) 722-4072
Fax: (614) 722-5893
Email: MartinPT@pediatrics.ohio-state.edu

Education & Training:
University of California, Berkeley, Ph.D. in Biochemistry with Daniel E. Koshland, Jr. Washington University Medical School, postdoctoral fellow in Neurobiology with Joshua Sanes
Neurosciences at the University of California, San Diego, Assistant and Associate Professor
Center for Gene Therapy, and The Ohio State University Medical School, Associate Professor of Pediatrics and of Physiology and Cell Biology

Research Interest:
Dr. Martin’s laboratory studies functional roles for glycosylation in the mammalian development and in neuromuscular disorders. Current work involves understanding therapeutic roles for glycosyltransferases in skeletal muscle and heart and assessing their impact on neuromuscular disease progression.  Other work relates to the study of genes that stimulate skeletal muscle growth. In addition, the laboratory works on projects involving the development of therapeutics for Alzheimer’s disease, the glycobiology of adult neural stem cells, and pediatric cancer.

Selected Publications:

  • Xu, R., Chandrasekharan, K., Yoon, J.H., Camboni, M., and Martin, P.T. (2007) Overexpression of the CT GalNAc transferase inhibits muscular dystrophy in the dyW mouse model of congenital muscular dystrophy 1A.  Am. J. Pathol. 171:181-199.
  • Martin, P.T. (2007) Congenital muscular dystrophies involving the O-mannose pathway.  Curr. Mol. Med., 7:417-425.
  • Haidet, A.M., Rizo, L., Handy, C., Umapathi, P., Eagle, A., Shilling, C., Boue, D., Martin, P.T., Sahenk, Z., Mendell, J.R., and Kaspar, B.K. (2008) Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  Proc. Natl. Acad. Sci. USA 105: 4318-4322.
  • Martin, P.T., Shelton, G.D., Dickinson, P.J., Sturges, B.K., Xu, R., LeCouteur, R.A., Guo, L.T., Grahn, R.A., Lo, H.P., North, K.N., Malik, R., Engvall, E., and Lysons, L.A. (2008) Muscular dystrophy associated with alpha-dystroglycan deficiency in Sphynx and Devon Rex cats.  Neuromuscular Disorders 18:942-952.
  • Kim, M-L., Chandrasekharan, K., Glass, M., Shi, S., Stahl, M., Kaspar, B., Stanley, P., and Martin, P.T. (2008) O-fucosylation of muscle agrin determines its ability to cluster acetylcholine receptors.  Mol. Cell. Neurosci. 39:452-464.
  • Chandrasekharan, K. and Martin, P.T. (2009) Embryonic overexpression of Galgt2 inhibits skeletal muscle growth via activation of myostatin signaling.  Muscle and Nerve, 39:25-41.
  • Martin, P.T., Xu, R., Rodino, L.R., Oglesbay, E., Camboni, M., Montgomery, C., Shontz, K., Chicoine, L, Clark, K.R., Sahenk, Z., Mendell, J., and Janssen, P.M.L. (2009) Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild type mice.  Am. J. Physiol. Cell Physiol., 296:C476-488.