Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease

Paul Janssen, PH. D.Paul Janssen , Ph.D.

Physiology & Cell Biology
207a Hamilton Hall
1645 Neil Avenue
Columbus, OH 43210

Phone: (614) 247-7838
Email: janssen.10@osu.edu

Education & Training:
Utrecht University, Netherlands, 1994 B.S.& M.S. in Medical Biology
Utrecht University, Netherlands, 1997 Ph.D. in Cardiac Physiology
Universities of Freiburg and Göttingen, Germany, 2000 Postdoctoral Fellow
Johns Hopkins University, Baltimore, 2002 Research Associate

Research Interest:
Research in the Janssen lab focuses on various aspects of myocardial relaxation. Cardiac relaxation is no longer thought to be a mere passive process that logically follows contraction, but is a highly regulated process, involving interactions between calcium removal systems and mechanical molecular motors. We study relaxation using a minimalized systems approach, in which we have the advantage of working in a sub-organ level model (multicellular trabeculae) that still encompasses all the electrical, biochemical, and contractile functions of the whole heart, yet is small enough to control in vitro while allowing for assessment of intracellular events, such as calcium transients. We use explanted and donor human hearts for most of our research, and collaborate with 15+ other PI’s on this human heart tissue to further our understanding of cardiac pathology. Several additional research areas of interest in the lab, again often in collaboration with other muscle group investigators, include skeletal muscle function in health and in various muscular dystrohies, the role of frequency-dependent activation of the heart, and pharmacological intervention in hypertrophic processes and contractility and kinetics.

Selected Publications:

  • Milani-Nejad N, Chung JH, Canan BD, Fedorov VV, Whitson BA, Kilic A, Mohler PJ, Janssen PML. Increased cross-bridge recruitment contributes to transient increase in force generation beyond maximal capacity in human myocardium. J Mol Cell Cardiol. 2017:114;116-123. PMID: 29141185
  • Elnakish MT, Canan BD, Kilic A, Mohler PJ, Janssen PML. Effects of Zacopride, a Moderate IK1 channel agonist, on Triggered Arrhythmia and Contractility in Human Ventricular Myocardium. Pharmacological Research, 2017;115:309-318. PMID 27914945
  • Lowe J, Floyd KT, Rastogi N, Schultz EJ, Chadwick JA, Swager SA, Zins JG, Kadakia FK, Smart S, Gomez-Sanchez EP, Gomez-Sanchez CE, Raman SV, Janssen PML*, Rafael-Fortney JA*. Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice. J. Neuromusc. Diseases, 2016;3:395-404, *contributed equally. PMID 27822449
  • Janssen PML, Biesiadecki BJ, Ziolo MT, Davis JP. The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve. Circ. Res. 2016;119:418-422. PMID 27458197
  • Milani-Nejad N, Chung JH, Canan BD, Davis JP, Fedorov VV, Higgins SD, Kilic A, Mohler PJ, Janssen PML. Insights into Length-Dependent Regulation of Cardiac Cross-Bridge Cycling kinetics in Human Myocardium. Archives of Biochemistry and Biophysics, 2016;601:48-55. PMID 26854725

NCBI link: http://www.ncbi.nlm.nih.gov/myncbi/browse/collection/41146939/?sort=date&direction=descending