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Scott Q. Harper , Ph.D.
Assistant Professor
The Ohio State University School of Medicine
Department
of Pediatrics
Nationwide Children's Research Institute
700 Children's Drive, Rm. WA3015
Columbus, OH 43205
Phone: (614) 355-2893
Email: Scott.Harper@Nationwidechildrens.org
Education & Training:
Saginaw Valley State University, Saginaw, MI, 1996 BS in Biology
University
of Michigan Medical School, 2002, Ph.D. in Cellular and Molecular Biology
University
of Iowa College of Medicine, Iowa City, 2007, Postdoctoral Fellow
Research Interest:
The Harper Lab is pursuing three major projects related to muscular
dystrophy. First,
we are interested in understanding the molecular mechanisms underlying facioscapulohumeral
muscular dystrophy (FSHD). Second, we are developing RNAi-mediated gene
therapies as potential treatments for dominant muscular dystrophies. Finally,
we are investigating microRNA involvement in common dystrophy-related pathways. Additionally,
in a corollary study to our RNAi therapy for muscular dystrophy project, we are
developing a potential gene therapy for alveolar rhabdomyosarcoma using microRNAs
targeting PAX3-FKHR translocations. The Harper Lab utilizes a broad
range of tools, including molecular techniques, biochemistry, viral vectors,
and mouse and zebrafish models of disease.
Selected Publications:
- S.Q. Harper, M. Hauser, C. DelloRusso, D. Duan, R.W. Crawford,
S. Phelps, H.A. Harper, A.S. Robinson, J.F. Engelhardt, S.V. Brooks,
and J.S. Chamberlain. (2002) Modular flexibility of dystrophin: Implications
for gene therapy of DMD. Nature Medicine, 8(3), 253-261.
- H. Xia, Q. Mao, S.L. Eliason, S.Q. Harper, I.H. Martins, H.T. Orr,
H.L. Paulson, L. Yang, R.M. Kotin, and B.L. Davidson. RNAi suppresses
polyglutamine-induced neurodegeneration in a model of spinocerebellar
ataxia. (2004) Nature Medicine 10(8), 816-820.
- S.Q. Harper, P.D. Staber, X. He, S.L. Eliason, I.H. Martins, L. Yang,
H.L. Paulson, R.M. Kotin, and B.L. Davidson. RNA interference
improves behavioral and neuropathological abnormalities in a mouse
model for Huntington’s disease. (2005) Proceedings of the
National Academy of Sciences, USA. 102(16), 5820-5825.
- B.L. Davidson and S.Q. Harper. Viral delivery of short hairpin
RNAs. (2005) Methods in Enzymology 392, 145-173.
- S.Q. Harper, P.D. Staber, C.R. Beck, S.K. Fineberg, C.S. Stein, D.
Ochoa, and B.L. Davidson. Optimization of feline immunodeficiency
viral vectors for RNA interference. (2006), Journal of Virology 80(19),
9371-9380.
- J.L. McBride*, R.L. Boudreau*, S.Q. Harper* (shared first authorship),
A. Mas Monteys, P.D. Staber, I. Martins, B. Gilmore, H. Burstein, R.W.
Peluso, B. Polisky, B.J. Carter, and B.L. Davidson. MicroRNA
shuttles mitigate short-hairpin RNA mediated toxicity in the brain:
Implications for therapeutic development of RNA interference. (2008) Proceedings
of the National Academy of Sciences, USA105(15):5868-73.
- Packer, Y. Xing, S.Q. Harper, L. Jones, and B.L. Davidson. The
bi-functional microRNA mir9/mir9* regulates REST and coREST and is
down-regulated in Huntington’s disease. (2008) Journal
of Neuroscience, 28(53):14341-6.
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