Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease

Peter Reiser, PH. D.Peter J. Reiser, Ph.D.

The Ohio State University Medical Center
Department of Oral Biology
4165 Postle Hall
305 West 12th Avenue
Columbus OH 43210

Office Phone: (614) 292-8476
Lab Phone: (614) 247-7335
Email: reiser.17@osu.edu

Education & Training:
Ohio State University, PhD, 1981

Case Western Reserve University, 1983 American Heart Association Postdoctoral Fellow
University of Wisconsin, Madison, 1986 National Institutes of Health Postdoctoral Fellow

Research Interest:
My research is focused on the roles of sarcomeric protein isoforms in regulating contractile properties of muscle. Specific areas of interest include craniofacial (extraocular, jaw-closing and laryngeal) muscles, limb skeletal muscles and cardiac muscle, with an emphasis on comparative muscle physiology and biochemistry. The approach is based primarily on analyses of contractile properties and protein composition of single, isolated muscle cells. Another area of interest is studying mechanisms that contribute to the profound fatigue and weakness experienced by cancer patients (cancer cachexia).

Selected Publications:

  • Bicer, S. and P.J. Reiser (2004). Myosin light chain isoform expression among single mammalian skeletal muscle fibers: species variations. J. Muscle Res. Cell Motil., 25:623-633.
  • Bergrin, M., S. Bicer, C.A. Lucas and P.J. Reiser (2006). Three-dimensional compartmentalization of myosin heavy chain and light chain isoforms within dog thyroarytenoid muscle. Am. J. Physiol., 290:C1446-C1458.
  • Reiser, P.J. and S. Bicer (2006). Multiple isoforms of myosin light chain 1 in pig diaphragm slow fibers: correlation with maximal shortening velocity and force generation. Arch. Biochem. Biophys., 456:112-118.
  • Bicer, S. and P.J. Reiser (2007). Variations in apparent mass of mammalian fast-type myosin light chains correlate with species body size, from shrew to elephant. Am. J. Physiol., 292:R527 - R534.
  • Babu, G.J., P. Bhupathy, V. Timofeyev, N.N. Petrashevskaya, P.J Reiser, N. Chiamvimonvat and M. Periasamy (2007). Ablation of sarcolipin enhances sarcoplasmic reticulum calcium transport and atrial contractility. Proc. Nat. Acad. Sci. (USA), 104:17867-17872.
  • Bicer, S., P.J. Reiser, S. Ching, and N. Quan. (2008). Induction of muscle weakness by local inflammation: an experimental animal model. Inflammation Res., 58:175-83.
  • Reiser, PJ, Bicer, S, Patel, R, An, Y, Chen, Q, Quan, (2010) The Myosin Light Chain 1 Isoform Associated with Masticatory Myosin Heavy Chain in Mammals and Reptiles is Embryonic/atrial MLC1. N. J. Exp. Biol., 213:1633-1642.
  • Tian, M., Nishijima, Y., Asp, M.L., Stout, M.B., Reiser, P.J. and Belury, M.A. (2010). Cardiac alterations in cancer-induced cachexia in mice. Int. J. Oncology, 37:347-353. DOI: 10.3892/ijo_00000683.
  • Reiser, P.J. (2010). Challenges in skeletal muscle physiology. Frontiers in Skeletal Muscle Physiology, doi: 10.3389/fphys.2010.00151.
  • Bicer, S., Patel, R.J., Williams, J.B. and Reiser, P.J. (2011). Patterns of tropomyosin and troponin-T isoform expression in jaw-closing muscles of mammals and reptiles that express masticatory myosin. J. Exp. Biol., 214:1077-1085.
  • Liu, H., Blough, E.R., Arvapalli, R., Wang, Y., Paturi, S., Katta, A., Reiser, P.J., Harris, R., Nepal, N. and Wu, M. (2012). Regulation of contractile proteins and protein translational signaling in disused muscle. Cell. Physiol. Biochem., 30:1202-1214