Peter J. Reiser, Ph.D.
The Ohio State University Medical Center
Department of Oral Biology
4165 Postle Hall
305 West 12th Avenue
Columbus OH 43210
Office Phone: (614) 292-8476
Lab Phone: (614) 247-7335
Education & Training:
Ohio State University, PhD, 1981
Case Western Reserve University, 1983 American Heart Association Postdoctoral Fellow
University of Wisconsin, Madison, 1986 National Institutes of Health Postdoctoral Fellow
My research is focused on the roles of sarcomeric protein isoforms in regulating contractile properties of muscle. Specific areas of interest include craniofacial (extraocular, jaw-closing and laryngeal) muscles, limb skeletal muscles and cardiac muscle, with an emphasis on comparative muscle physiology and biochemistry. The approach is based primarily on analyses of contractile properties and protein composition of single, isolated muscle cells. Another area of interest is studying mechanisms that contribute to the profound fatigue and weakness experienced by cancer patients (cancer cachexia).
- Liu H, Blough ER, Arvapalli R, Wang Y, Reiser PJ, Paturi S, Katta A, Harris R, Nepal N, Wu M. Regulation of contractile proteins and protein translational signaling in disused muscle. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2012;30:1202-14.
- Bicer S, Reiser PJ. Complex tropomyosin and troponin T isoform expression patterns in orbital and global fibers of adult dog and rat extraocular muscles. Journal of muscle research and cell motility. 2013;34:211-31.
- Reiser PJ, Welch KC, Jr., Suarez RK, Altshuler DL. Very low force-generating ability and unusually high temperature dependency in hummingbird flight muscle fibers. The Journal of experimental biology. 2013;216:2247-56.
- Reiser PJ, Bicer S. Electrophoretic separation of reptilian skeletal and cardiac muscle myosin heavy chain isoforms: dependence on gel format. Electrophoresis. 2014;35:2615-20.
- Reiser PJ, Moravec CS. Sex differences in myosin heavy chain isoforms of human failing and nonfailing atria. American journal of physiology Heart and circulatory physiology. 2014;307:H265-72.
- Brundage EA, Biesiadecki BJ, Reiser PJ. Nucleotide and protein sequences for dog masticatory tropomyosin identify a novel Tpm4 gene product. Journal of muscle research and cell motility. 2015;36:339-47.
- Devine RD, Bicer S, Reiser PJ, Velten M, Wold LE. Metalloproteinase expression is altered in cardiac and skeletal muscle in cancer cachexia. American journal of physiology Heart and circulatory physiology. 2015;309:H685-91.
- McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Frontiers in physiology. 2015;6:242.
- Norden DM, Bicer S, Clark Y, Jing R, Henry CJ, Wold LE, Reiser PJ, Godbout JP, McCarthy DO. Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function. Brain, behavior, and immunity. 2015;43:76-85.
- Norden DM, McCarthy DO, Bicer S, Devine RD, Reiser PJ, Godbout JP, Wold LE. Ibuprofen ameliorates fatigue- and depressive-like behavior in tumor-bearing mice. Life sciences. 2015;143:65-70.
- Stevens SC, Velten M, Youtz DJ, Clark Y, Jing R, Reiser PJ, Bicer S, Devine RD, McCarthy DO, Wold LE. Losartan treatment attenuates tumor-induced myocardial dysfunction. Journal of molecular and cellular cardiology. 2015;85:37-47.
- Young BA, Dumais J, John N, Lyons B, Macduff A, Most M, Reiser NA, Reiser PJ. Functional Segregation within the Muscles of Aquatic Propulsion in the Asiatic Water Monitor (Varanus salvator). Frontiers in physiology. 2016;7:380.
- Devine RD, Bicer S, Reiser PJ, Wold LE. Increased hypoxia-inducible factor-1alpha in striated muscle of tumor-bearing mice. American journal of physiology Heart and circulatory physiology. 2017;312:H1154-h62.
- O'Neill MC, Umberger BR, Holowka NB, Larson SG, Reiser PJ. Chimpanzee super strength and human skeletal muscle evolution. Proceedings of the National Academy of Sciences of the United States of America. 2017;114:7343-8.