Ohio State - Nationwide Children's Hospital - Research For Muscle Biology and Disease

Mark T Ziolo, Ph.D.Mark Ziolo, FAHA
Associate Professor

Dept of Physiology and Cell Biology
Dept of Internal Medicine/Cardiovascular Medicine
Investigator, Davis Heart & Lung Research Institute
The Ohio State University
304 Hamilton Hall
1645 Neil Avenue
Columbus, OH  43210-1218

Phone: (614) 688-7905
Email: ziolo.1@osu.edu

Education & Training:
University of Illinois-Chicago, 1999 Ph.D. in Physiology and Biophysics
Loyola University, Chicago, 2004 Postdoctoral Fellow

Research Interest:
My research area is cardiovascular physiology. The focus of my research is how the nitroso-redox equilibrium modulates cardiac contractile function (mechanical and electrical) and heart structure. Nitric oxide (NO), produced via NO synthases, is tightly coordinated with other redox molecules (e.g., superoxide anion) to modulate heart function/structure. A key contributor to the contractile dysfunction and remodeling of many cardiomyopathies is nitroso-redox disequilibrium. The lab is currently investigating the therapeutic potential of a novel compound that restores the nitroso-redox equilibrium in various cardiomyopathies. Other research interests include the molecular mechanisms of skeletal muscle wasting after myocardial infarction.

Selected Publications:

  • Feldman DS, Elton TS, Sun B, Martin MM, Ziolo MT. Mechanisms of Disease: Detrimental Adrenergic Signaling in Acute Decompensated Heart Failure. Nat Clin Pract Cardiovasc Med. 5:208-218, 2008.
  • Wang H, Kohr MJ, Traynham CJ, Ziolo MT. Phosphodiesterase 5 Restricts NOS3/Soluble Guanylate Cyclase Signaling to L-type Ca2+ current in Cardiac Myocytes. J Mol Cell Cardiol. 47(2):304-14, 2009.
  • Kohr MJ, Traynham CJ, Davis JP, Ziolo MT. cAMP-independent activation of protein kinase A by the Peroxynitrite Generator SIN-1 elicits positive inotropic effects in cardiomyocytes. J Mol Cell Cardiol. 48(4):645-8, 2010. Rapid Communication.
  • Wang H, Viatchenko-Karpinski S, Sun J, Gyorke I, Benkusky NA, Kohr MJ, Valdivia HH, Murphy E, Gyorke S, Ziolo MT. Regulation of Myocyte Contraction via Neuronal Nitric Oxide Synthase: Role of Ryanodine Receptor S-Nitrosylation. J Physiol. 588(Pt 15):2905-17, 2010.
  • Roof SR, Shannon TR, Janssen PM, Ziolo MT. Effects of increased systolic Ca2+ and phospholamban phosphorylation during β-adrenergic stimulation on Ca2+ transient kinetics in cardiac myocytes. AJP-Heart. 301(4):H1570-8, 2011.
  • Wang H, Bonilla Mercado IM, Huang X, He Q, Kohr MJ, Carnes CA, Ziolo MT. Prolonged action potential and afterdepolarizations are not due to changes in potassium currents in NOS3 knockout ventricular myocytes. Journal of Signal Transduction. vol. 2012, Article ID 645721, doi:10.1155/2012/645721, 2012.
  • Roof SR, Biesiadecki BJ, Davis JP, Janssen PML, Ziolo MT. Effects of increased systolic Ca2+ and β-adrenergic stimulation on Ca2+ transient decline in NOS1 knockout cardiac myocytes. Nitric Oxide. 27(4):242-7, 2012.
  • Traynham CJ, Roof SR, Wang H, Prosak RA, Tang L, Viatchenko-Karpinski S, Ho HT, Racoma IO, Catalano DJ, Huang X, Han Y, Kim SU, Gyorke S, Billman GE, Villamena FA, Ziolo MT. Diesterifed nitrone rescues nitroso-redox levels and increases myocyte contraction via increased SR Ca2+ handling. PLoS ONE. 7(12):e52005, 2012.
  • Kohr MJ, Roof SR, Zweier JL, Ziolo MT. Modulation of myocardial contraction by peroxynitrite. Frontiers in Physiology. In Press. 2012.
  • Roof SR, Tang L, Ostler JE, Periasamy M, Gyorke S, Billman GE, Ziolo MT. Neuronal nitric oxide synthase is indispensable for the adaptive contractile effects of exercise. Basic Res Cardiol. In Press. 2013.