Center for Muscle Health and Neuromuscular Disorders - Ohio State University and Nationwide Children's Hospital

2012 MVIMG 747 – Neuromuscular Biology and Disease

Syllabus – MVIMG 747 Neuromuscular Biology and Disease, Spring 2012

Thursdays 4-5pm, HRLI 165

Instructors: Arthur Burghes, PhD and Denis Guttridge, PhD

• WEEK 1 – Introduction to neuromuscular disorders DMD to ALS – John Kissel, MD

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• WEEK 2 – Pathology of neuromuscular disease: muscle and nerve – Zarife Sahenk, MD, PhD

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• WEEK 3 – Development of the motor neuron and sensory neuron – Christine Beattie, PhD

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• WEEK 4 – The structure of the NMJ (overview of electrophysiology) – Steve Kolb, MD, PhD

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• WEEK 5 – The development of skeletal muscle – POSTPONED

• WEEK 6 – How to measure heart and skeletal muscle physiologically – Paul Jansen, PhD

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• WEEK 7 – Signaling pathways that regulate muscle mass – Denis Guttridge, PhD

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• WEEK 8 – The role of glycosylation in neuromuscular disorders – Paul Martin, PhD

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• WEEK 9 – Therapeutic strategies of motor neuron diseases: SMA and ALS – Arthur Burghes, PhD

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• WEEK 10 – Development of novel therapies for the dystrophies translation to the clinic – Jerry Mendell, MD

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