Hua Zhu, Ph.D.

The Ohio State University Wexner Medical Center
Department of Surgery
Davis Heart and Lung Research Institute,
460 W 12th Ave. BRT396
Columbus, OH  43210

Phone: (614) 292-2130


Hua Zhu, Ph.D.

Education & Training:
Sichuan University, China 2000, BS, Biochemistry
Chinese Academy of Sciences, China 2006, PhD, Cellular and Molecular Biology
University of Medicine and Dentistry of New Jersey, NJ, 2006-2012, Postdoctoral Fellow

Research Interest:
My laboratory works on understanding the molecular and cellular mechanisms of striated muscle injury, repair, and regeneration. We study the roles of proteins in triad structure of skeletal muscle in muscle physiology and diseases. We are also interested in different cell death pathways, such as apoptosis, autophagy, necroptosis, and pyrotptosis, in tissue injury. We try to identify regulatory factors of these pathways to promote tissue repair. Finally, my laboratory studies the role of novel non-coding RNAs in tissue injury and repair. My laboratory uses induced pluripotent stem cells, different transgenic mouse models, and gene editing approaches in our projects.

Selected Publications:

  • Geng, B., Wang, X., Park, KH., Lee, KE., Kim, J., Chen, P., Zhou, X., Tan, T., Yang, C., Zou, X., Janssen, PM., Cao, L., Ye, L., Wang, X., Cai, C., Zhu, H.*. (2022) UCHL1 protects against ischemic heart injury via activating HIF-1α signal pathway. Redox Biology. 52 (2022) 102295.
  • Wang, Q., Park, KH., Geng, B., Chen, P., Yang, C., Jiang, Q., Yi, F., Tan, T., Zhou, X., Bian, Z., Ma, J., Zhu, H.*. (2022) MG53 inhibits necroptosis through ubiquitination-dependent RIPK1 degradation for cardiac protection following ischemia/reperfusion injury. Frontiers in Cardiovascular Medicine. 9:868632. doi: 10.3389/fcvm.2022.868632.
  • Burdette, B., Esparza, A., Zhu, H.,* and Wang, S.* (2021) Gasdermin D in Pyroptosis. Acta Pharmaceutica Sinca B. 11(9):2768-2782.
  • Geng, B., Choi, KH., Wang, S., Chen, P., Pan, X., Dong, N., Ko, JK.*, Zhu, H.* (2020) A Simple, quick, and efficient CRISPR/Cas9 genome editing method for human induced pluripotent stem cells (Cover Story). Acta Pharmacologica Sinica. 41(11):1427-1432. doi: 10.1038/s41401-020-0452-0. PMCID: PMC7656785.
  • Bian, Z., Wang, Q., Zhou, X., Tan, T., Park, K., Adesanya, T., Sermersheim, M., Yi, F., Wang, X., Wu, J., Gummper, K., Jiang, Q., He, D., Lin, P., Li, H., Guan, J., Zhou, J., Kohr, M., Zeng, C., Zhu, H.* , Ma, J.* Sustained Elevation of MG53 in the Bloodstream Increases Tissue Regenerative Capacity without Compromising Metabolic Function. Nature Communications. 2019 10:4659. Doi: 10.1038/s41467-019-12483-0
  • Zhang, J., Chen, W., Alvarez, JB., Jia, K., Shi, L., Wang, Q., Zou, N., He, K., Zhu, H.* Cancer immune checkpoint blockade therapy and its associated autoimmune cardiotoxicity. Acta Pharmacologica Sinica. 2018 Jul 10. doi: 10.1038/s41401-018-0062-2.

My NCBI Link: